:root {
  --bg: #f4efe6;
  --bg-alt: #fdf9f2;
  --paper: rgba(255, 252, 245, 0.9);
  --ink: #201911;
  --muted: #6f6458;
  --line: #dbcdbd;
  --brand: #1d6f63;
  --brand-soft: #ddf1ec;
  --accent: #c45a38;
  --accent-soft: #fce5da;
  --success: #1f8f64;
  --warning: #b86512;
  --danger: #ab3f4e;
  --radius-lg: 26px;
  --radius-md: 18px;
  --radius-sm: 12px;
  --shadow-1: 0 14px 34px rgba(44, 29, 12, 0.1);
}

* {
  box-sizing: border-box;
}

html,
body {
  margin: 0;
  min-height: 100%;
}

body {
  position: relative;
  overflow-x: hidden;
  font-family: "Outfit", sans-serif;
  color: var(--ink);
  background:
    radial-gradient(circle at 8% 10%, rgba(29, 111, 99, 0.16), transparent 30%),
    radial-gradient(circle at 88% 5%, rgba(196, 90, 56, 0.13), transparent 30%),
    radial-gradient(circle at 95% 82%, rgba(29, 111, 99, 0.1), transparent 38%),
    linear-gradient(160deg, var(--bg), var(--bg-alt));
}

body::before {
  content: "";
  position: fixed;
  inset: -8rem;
  pointer-events: none;
  background-image: linear-gradient(rgba(81, 64, 48, 0.06) 1px, transparent 1px),
    linear-gradient(90deg, rgba(81, 64, 48, 0.06) 1px, transparent 1px);
  background-size: 32px 32px;
  mask-image: radial-gradient(circle at center, black 38%, transparent 76%);
  opacity: 0.42;
  z-index: -1;
}

h1,
h2,
h3 {
  font-family: "Fraunces", serif;
  letter-spacing: 0.01em;
  margin: 0;
}

p {
  margin: 0;
}

a,
button,
input,
select,
output {
  font: inherit;
}

.page-shell {
  width: min(1160px, 92vw);
  margin: 1.2rem auto 2.6rem;
  display: grid;
  gap: 1rem;
}

.topbar {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 1rem;
  padding: 0.72rem 0.8rem;
  border: 1px solid rgba(119, 91, 62, 0.24);
  border-radius: 16px;
  background: rgba(255, 251, 243, 0.82);
  backdrop-filter: blur(9px);
  box-shadow: 0 10px 26px rgba(62, 43, 24, 0.07);
  position: sticky;
  top: 0.8rem;
  z-index: 9;
}

.brand {
  display: inline-flex;
  align-items: baseline;
  gap: 0.44rem;
  text-decoration: none;
  color: var(--ink);
}

.brand-mark {
  font-family: "Fraunces", serif;
  font-size: 1.16rem;
  font-weight: 700;
  letter-spacing: 0.04em;
  color: var(--brand);
}

.brand-word {
  font-size: 0.94rem;
  font-weight: 700;
  color: #433325;
}

.menu-toggle {
  display: none;
  border: 1px solid var(--line);
  background: #fff;
  color: #412f21;
  border-radius: 999px;
  padding: 0.36rem 0.72rem;
  font-size: 0.84rem;
  font-weight: 600;
}

.nav-links {
  display: flex;
  flex-wrap: wrap;
  gap: 0.44rem;
}

.nav-links a {
  color: #5b4f43;
  text-decoration: none;
  font-size: 0.86rem;
  font-weight: 500;
  padding: 0.34rem 0.56rem;
  border-radius: 999px;
  transition: background-color 150ms ease, color 150ms ease;
}

.nav-links a:hover {
  background: #f1e6d8;
  color: #2d241e;
}

.nav-links a[aria-current="page"] {
  background: var(--brand-soft);
  color: #1f665a;
}

.section-card {
  border: 1px solid rgba(120, 94, 70, 0.2);
  background: var(--paper);
  border-radius: var(--radius-lg);
  padding: 1.2rem;
  box-shadow: var(--shadow-1);
}

.hero-grid {
  display: grid;
  grid-template-columns: 1.15fr 0.85fr;
  gap: 1rem;
}

.eyebrow {
  text-transform: uppercase;
  letter-spacing: 0.12em;
  font-size: 0.71rem;
  font-weight: 700;
  color: #4a8f82;
}

.hero-copy h1,
.doc-hero h1 {
  margin-top: 0.5rem;
  font-size: clamp(2rem, 5vw, 3.45rem);
  line-height: 1.02;
}

.lead {
  margin-top: 0.7rem;
  color: #4f4438;
  font-size: 1.02rem;
  max-width: 62ch;
}

.quick-facts {
  margin-top: 0.9rem;
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 0.6rem;
}

.quick-facts article {
  background: #fffbf5;
  border: 1px solid #eadfce;
  border-radius: var(--radius-sm);
  padding: 0.68rem;
}

.quick-facts h2 {
  font-size: 1rem;
}

.quick-facts p {
  margin-top: 0.34rem;
  color: var(--muted);
  font-size: 0.9rem;
}

.metric-panel {
  border-radius: var(--radius-md);
  border: 1px solid rgba(52, 118, 106, 0.25);
  background: linear-gradient(165deg, #f9fffd, #edf8f5);
  padding: 0.88rem;
}

.metric-label {
  font-size: 0.8rem;
  letter-spacing: 0.04em;
  text-transform: uppercase;
  color: #4f7f77;
}

.metric-value {
  margin-top: 0.28rem;
  font-family: "Fraunces", serif;
  font-size: clamp(2.8rem, 8vw, 4.9rem);
  line-height: 0.95;
  color: #1d6f63;
}

.metric-status {
  margin-top: 0.46rem;
  font-weight: 700;
}

.metric-sub {
  margin-top: 0.26rem;
  color: #4f635d;
  font-size: 0.93rem;
}

.metric-grid {
  margin-top: 0.8rem;
  display: grid;
  gap: 0.52rem;
}

.metric-grid article {
  background: #fffcf7;
  border: 1px solid rgba(145, 164, 156, 0.34);
  border-radius: var(--radius-sm);
  padding: 0.58rem;
}

.metric-grid h2 {
  font-size: 0.95rem;
}

.metric-grid p {
  margin-top: 0.24rem;
  color: #2d4f48;
  font-weight: 600;
}

.section-head {
  display: grid;
  gap: 0.26rem;
}

.section-head h2 {
  font-size: clamp(1.45rem, 2.8vw, 2rem);
}

.section-head-spread {
  display: flex;
  align-items: flex-end;
  justify-content: space-between;
  gap: 1rem;
}

.lab-layout {
  margin-top: 0.82rem;
  display: grid;
  grid-template-columns: 1.3fr 0.7fr;
  gap: 0.8rem;
}

.control-grid {
  display: grid;
  gap: 0.62rem;
}

.control-grid label,
.signal-controls label {
  display: grid;
  gap: 0.38rem;
  font-size: 0.87rem;
  color: #52473c;
  background: #fffdf8;
  border: 1px solid #e5d8c6;
  border-radius: var(--radius-sm);
  padding: 0.64rem;
}

input[type="range"] {
  accent-color: var(--brand);
}

output {
  color: var(--brand);
  font-weight: 700;
  font-size: 0.84rem;
}

.formula-card {
  border-radius: var(--radius-md);
  border: 1px solid #e7d8c6;
  background: #fff8ef;
  padding: 0.74rem;
  color: #4f4337;
  display: grid;
  gap: 0.42rem;
}

.formula-card h3 {
  font-size: 1.14rem;
}

.formula-card strong {
  color: #7e361f;
}

.timeline-head {
  display: flex;
  justify-content: space-between;
  align-items: flex-end;
  gap: 1rem;
  flex-wrap: wrap;
}

.timeline-head h2 {
  margin-top: 0.26rem;
  font-size: clamp(1.45rem, 2.8vw, 2rem);
}

.crossing-note {
  color: #6f6256;
  font-size: 0.91rem;
}

.timeline-list {
  margin-top: 0.86rem;
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(185px, 1fr));
  gap: 0.56rem;
}

.timeline-row {
  border: 1px solid #e5d5c1;
  background: #fffdf8;
  border-radius: var(--radius-sm);
  padding: 0.62rem;
}

.timeline-row-head {
  display: flex;
  justify-content: space-between;
  align-items: baseline;
  gap: 0.6rem;
}

.timeline-row-head strong {
  font-size: 1.03rem;
}

.timeline-row-ratio {
  font-weight: 700;
  color: #5c5043;
}

.timeline-row-sub {
  margin-top: 0.34rem;
  color: #6e6155;
  font-size: 0.87rem;
}

.timeline-bar {
  margin-top: 0.44rem;
  height: 8px;
  border-radius: 999px;
  background: #efe4d6;
  overflow: hidden;
}

.timeline-fill {
  height: 100%;
  width: 0;
  border-radius: inherit;
  background: linear-gradient(90deg, #18826f, #de7d41);
}

.track-grid,
.focus-grid,
.milestone-grid {
  margin-top: 0.76rem;
  display: grid;
  grid-template-columns: repeat(3, minmax(0, 1fr));
  gap: 0.6rem;
}

.track-card,
.focus-card,
.milestone-card {
  border: 1px solid #e7dac9;
  border-radius: var(--radius-sm);
  background: #fffdf8;
  padding: 0.72rem;
}

.track-card h3,
.focus-card h3,
.milestone-card h3 {
  font-size: 1.08rem;
  line-height: 1.18;
}

.track-card p,
.focus-card p,
.milestone-card p {
  margin-top: 0.36rem;
  color: var(--muted);
  font-size: 0.9rem;
}

.track-card a {
  margin-top: 0.55rem;
  display: inline-block;
  color: #1d6f63;
  text-decoration: none;
  font-weight: 600;
}

.track-card a:hover {
  text-decoration: underline;
}

.milestone-step {
  text-transform: uppercase;
  font-size: 0.7rem;
  letter-spacing: 0.08em;
  color: #8c5f29;
  font-weight: 700;
}

.ghost-btn {
  border: 1px solid #dbc7b1;
  background: #fff8ee;
  color: #553e28;
  padding: 0.42rem 0.72rem;
  border-radius: 999px;
  font-size: 0.84rem;
  font-weight: 600;
  cursor: pointer;
}

.ghost-btn:hover {
  background: #f7e8d6;
}

.signal-controls {
  margin-top: 0.72rem;
  display: grid;
  grid-template-columns: minmax(0, 1fr) minmax(0, 240px);
  gap: 0.56rem;
}

.signal-controls input,
.signal-controls select {
  width: 100%;
  min-width: 0;
  text-overflow: ellipsis;
  border: 1px solid #dbcbb7;
  border-radius: 10px;
  background: #fff;
  color: #31261d;
  padding: 0.46rem 0.54rem;
}

.signal-meta {
  margin-top: 0.64rem;
  font-size: 0.87rem;
  color: #6c6054;
}

.signal-list {
  margin-top: 0.58rem;
  display: grid;
  gap: 0.54rem;
}

.signal-item {
  border: 1px solid #e5d8c9;
  border-radius: var(--radius-sm);
  padding: 0.62rem;
  background: #fffdf8;
}

.signal-item h3 {
  font-size: 1.02rem;
}

.signal-item-meta {
  margin-top: 0.2rem;
  color: #6b5f53;
  font-size: 0.84rem;
}

.signal-tags {
  margin-top: 0.45rem;
  display: flex;
  flex-wrap: wrap;
  gap: 0.34rem;
}

.signal-tags span {
  font-size: 0.74rem;
  padding: 0.2rem 0.42rem;
  border-radius: 999px;
  border: 1px solid #ddccbb;
  background: #fff9f0;
  color: #6f4c2e;
}

.ontology-export-link {
  text-decoration: none;
}

.ontology-controls {
  margin-top: 0.72rem;
  display: grid;
  grid-template-columns: 1fr;
  gap: 0.56rem;
}

.ontology-controls input {
  border: 1px solid #dbcbb7;
  border-radius: 10px;
  background: #fff;
  color: #31261d;
  padding: 0.46rem 0.54rem;
}

.ontology-layout {
  margin-top: 0.62rem;
  display: grid;
  grid-template-columns: 0.95fr 1.05fr;
  gap: 0.62rem;
}

.ontology-results {
  display: grid;
  gap: 0.5rem;
  align-content: start;
  max-height: 620px;
  overflow: auto;
  padding-right: 0.22rem;
}

.ontology-item {
  border: 1px solid #e5d8c9;
  border-radius: var(--radius-sm);
  padding: 0.62rem;
  background: #fffdf8;
  text-align: left;
}

button.ontology-item {
  cursor: pointer;
  width: 100%;
  transition: border-color 120ms ease, box-shadow 120ms ease;
}

button.ontology-item:hover {
  border-color: #cab499;
}

button.ontology-item.is-active {
  border-color: #2a8678;
  box-shadow: 0 0 0 2px rgba(42, 134, 120, 0.13);
}

.ontology-item h3 {
  font-size: 1.01rem;
  line-height: 1.18;
}

.ontology-item p {
  margin-top: 0.22rem;
  color: #6b5f53;
  font-size: 0.84rem;
}

.ontology-code {
  color: #1d6f63;
  font-weight: 700;
}

.ontology-detail {
  border: 1px solid #e5d8c9;
  border-radius: var(--radius-sm);
  padding: 0.7rem;
  background: #fffdf8;
  display: grid;
  gap: 0.42rem;
}

.ontology-detail h3 {
  font-size: 1.08rem;
  line-height: 1.2;
}

.ontology-muted {
  color: #6b5f53;
  font-size: 0.86rem;
}

.ontology-columns {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 0.62rem;
}

.ontology-columns section {
  border: 1px solid #ecdecd;
  border-radius: 10px;
  padding: 0.52rem;
  background: #fff;
}

.ontology-columns h4 {
  margin: 0;
  font-family: "Outfit", sans-serif;
  font-size: 0.88rem;
  text-transform: uppercase;
  letter-spacing: 0.05em;
  color: #574633;
}

.ontology-list {
  margin: 0.4rem 0 0;
  padding-left: 1rem;
  display: grid;
  gap: 0.25rem;
  font-size: 0.84rem;
  color: #4f4438;
}

.mindmap-shell {
  margin-top: 0.72rem;
  display: grid;
  grid-template-columns: minmax(0, 280px) minmax(0, 1fr);
  gap: 0.62rem;
}

.mindmap-panel {
  border: 1px solid #e7dac9;
  border-radius: var(--radius-sm);
  background: #fffdf8;
  padding: 0.62rem;
  display: grid;
  gap: 0.54rem;
  align-content: start;
}

.mindmap-tools {
  border: 1px solid #e7dac9;
  border-radius: 10px;
  background: #fff;
  padding: 0.52rem;
  display: grid;
  gap: 0.52rem;
}

.mindmap-tools-title {
  font-size: 0.75rem;
  font-weight: 700;
  text-transform: uppercase;
  letter-spacing: 0.06em;
  color: #5e4f3f;
}

.mindmap-zoom {
  display: grid;
  gap: 0.36rem;
}

.mindmap-zoom-buttons {
  display: inline-flex;
  border: 1px solid #d7c7b2;
  border-radius: 999px;
  overflow: hidden;
  width: fit-content;
}

.mindmap-zoom-buttons button {
  border: 0;
  border-right: 1px solid #e5d7c4;
  background: #fff;
  color: #3f3023;
  min-width: 2.2rem;
  padding: 0.32rem 0.5rem;
  cursor: pointer;
}

.mindmap-zoom-buttons button:last-child {
  border-right: 0;
}

.mindmap-zoom-buttons button:hover {
  background: #f8efe3;
}

.mindmap-zoom-value {
  font-size: 0.8rem;
  color: #685b4f;
}

.mindmap-filters-wrap {
  display: grid;
  gap: 0.34rem;
}

.mindmap-filters {
  display: grid;
  gap: 0.28rem;
  grid-template-columns: 1fr 1fr;
}

.mindmap-filter {
  display: inline-flex;
  align-items: center;
  gap: 0.3rem;
  border: 1px solid #e6d8c6;
  border-radius: 8px;
  background: #fffdfa;
  padding: 0.26rem 0.36rem;
  font-size: 0.76rem;
  color: #54483c;
  cursor: pointer;
}

.mindmap-filter input {
  margin: 0;
}

.mindmap-search {
  display: grid;
  gap: 0.38rem;
  font-size: 0.87rem;
  color: #52473c;
}

.mindmap-search input {
  border: 1px solid #dbcbb7;
  border-radius: 10px;
  background: #fff;
  color: #31261d;
  padding: 0.46rem 0.54rem;
}

.mindmap-results {
  display: grid;
  gap: 0.44rem;
  max-height: 480px;
  overflow: auto;
  padding-right: 0.18rem;
}

.mindmap-result-empty {
  border: 1px dashed #dac7b1;
  border-radius: 10px;
  background: #fff8ef;
  color: #6f6051;
  font-size: 0.84rem;
  padding: 0.54rem;
}

.mindmap-result {
  width: 100%;
  text-align: left;
  border: 1px solid #e5d8c9;
  border-radius: 10px;
  background: #fff;
  padding: 0.52rem;
  cursor: pointer;
  transition: border-color 120ms ease, box-shadow 120ms ease;
}

.mindmap-result:hover {
  border-color: #ccb79e;
}

.mindmap-result.is-active {
  border-color: #2a8678;
  box-shadow: 0 0 0 2px rgba(42, 134, 120, 0.13);
}

.mindmap-result h3 {
  font-size: 0.98rem;
  line-height: 1.15;
}

.mindmap-result p {
  margin-top: 0.18rem;
  color: #6b5f53;
  font-size: 0.8rem;
}

.mindmap-canvas {
  min-width: 0;
  border: 1px solid #e7dac9;
  border-radius: var(--radius-sm);
  background: #fffdf8;
  padding: 0.44rem;
}

.edge-matrix {
  margin-top: 0.9rem;
  border: 1px solid #e7dac9;
  border-radius: var(--radius-sm);
  background: #fffdf8;
  padding: 0.72rem;
}

.edge-matrix-head {
  display: flex;
  align-items: end;
  justify-content: space-between;
  gap: 1rem;
  margin-bottom: 0.55rem;
}

.edge-matrix-head h3 {
  margin-top: 0.12rem;
  font-size: 1.15rem;
}

.edge-matrix-head .signal-meta {
  margin: 0;
  text-align: right;
}

.edge-matrix-scroll {
  overflow-x: auto;
  border: 1px solid #e7dac9;
  border-radius: 10px;
  background: #fff;
}

.edge-matrix-table {
  width: 100%;
  min-width: 680px;
  border-collapse: collapse;
  font-size: 0.82rem;
}

.edge-matrix-table th,
.edge-matrix-table td {
  padding: 0.52rem 0.6rem;
  border-bottom: 1px solid #eee3d5;
  text-align: right;
  white-space: nowrap;
}

.edge-matrix-table th:first-child,
.edge-matrix-table td:first-child,
.edge-matrix-table th:nth-child(2),
.edge-matrix-table td:nth-child(2) {
  text-align: left;
}

.edge-matrix-table th {
  background: #f8efe3;
  color: #574633;
  font-size: 0.72rem;
  letter-spacing: 0.04em;
  text-transform: uppercase;
}

.edge-matrix-table tbody tr:last-child td {
  border-bottom: 0;
}

.edge-matrix-table tbody tr:hover {
  background: #fffbf5;
}

.edge-matrix-label {
  font-weight: 700;
  color: #3f3023;
}

.edge-matrix-predicate {
  display: block;
  margin-top: 0.1rem;
  color: #766858;
  font-size: 0.72rem;
}

.edge-matrix-bar {
  display: inline-block;
  width: 5rem;
  height: 0.38rem;
  margin-right: 0.38rem;
  overflow: hidden;
  vertical-align: middle;
  border-radius: 999px;
  background: #eee3d5;
}

.edge-matrix-bar::after {
  display: block;
  width: var(--edge-share, 0%);
  height: 100%;
  border-radius: inherit;
  background: #2a8678;
  content: "";
}

.edge-matrix-empty,
.edge-matrix-note {
  color: #6f6051;
  font-size: 0.8rem;
}

.edge-matrix-empty {
  padding: 0.8rem;
  text-align: left !important;
}

.edge-matrix-note {
  margin: 0.5rem 0 0;
}

.mindmap-stage {
  position: relative;
  min-height: 640px;
  border-radius: 12px;
  border: 1px solid #eadfce;
  overflow: hidden;
  cursor: grab;
  user-select: text;
  touch-action: none;
  background:
    radial-gradient(circle at 22% 16%, rgba(29, 111, 99, 0.12), transparent 34%),
    radial-gradient(circle at 84% 82%, rgba(196, 90, 56, 0.1), transparent 30%),
    linear-gradient(160deg, #fffdfa, #fbf4ea);
}

.mindmap-stage.is-panning {
  cursor: grabbing;
}

.mindmap-viewport {
  position: absolute;
  left: 0;
  top: 0;
  transform-origin: 0 0;
  will-change: transform;
}

.mindmap-lines {
  position: absolute;
  left: 0;
  top: 0;
  pointer-events: none;
}

.mindmap-nodes {
  position: absolute;
  left: 0;
  top: 0;
}

.mindmap-empty {
  position: absolute;
  inset: 50% auto auto 50%;
  transform: translate(-50%, -50%);
  border: 1px dashed #ccb79e;
  border-radius: 12px;
  padding: 0.7rem 0.8rem;
  color: #695c4f;
  background: #fffaf3;
  font-size: 0.9rem;
}

.mind-node {
  overflow-wrap: anywhere;
  position: absolute;
  transform: translate(-50%, -50%);
  width: min(180px, 28vw);
  border: 1px solid #decfbc;
  border-radius: 11px;
  padding: 0.42rem 0.5rem;
  background: #fff;
  text-align: left;
  box-shadow: 0 8px 18px rgba(50, 36, 22, 0.1);
}

button.mind-node {
  cursor: pointer;
}

button.mind-node.is-clickable:hover {
  box-shadow: 0 10px 22px rgba(40, 31, 20, 0.16);
}

.mind-node h3 {
  font-size: 0.88rem;
  line-height: 1.15;
}

.mind-node p {
  margin-top: 0.14rem;
  font-size: 0.76rem;
  color: #6f6053;
}

.mind-node.is-center {
  width: min(230px, 36vw);
  border-width: 2px;
  border-color: #2a8678;
  background: #f2fbf8;
  box-shadow: 0 14px 30px rgba(29, 111, 99, 0.2);
}

.mind-node.is-center h3 {
  font-size: 1rem;
}

.mind-group-tag {
  position: absolute;
  transform: translate(-50%, -50%);
  border-radius: 999px;
  border: 1px solid #d8cab8;
  background: #fff;
  padding: 0.18rem 0.5rem;
  font-size: 0.72rem;
  font-weight: 700;
  letter-spacing: 0.04em;
  text-transform: uppercase;
  color: #5f4f40;
}

.mind-node.is-therapy,
.mind-group-tag.is-therapy {
  border-color: rgba(29, 111, 99, 0.4);
  background: #eef8f5;
}

.mind-node.is-biomarker,
.mind-group-tag.is-biomarker {
  border-color: rgba(78, 127, 47, 0.38);
  background: #f1faec;
}

.mind-node.is-finding,
.mind-group-tag.is-finding {
  border-color: rgba(184, 101, 18, 0.38);
  background: #fff5ea;
}

.mind-node.is-symptom,
.mind-group-tag.is-symptom {
  border-color: rgba(139, 92, 28, 0.38);
  background: #fff7ed;
}

.mind-node.is-diagnostic,
.mind-group-tag.is-diagnostic {
  border-color: rgba(95, 75, 148, 0.36);
  background: #f4f1ff;
}

.mind-node.is-diffdx,
.mind-group-tag.is-diffdx {
  border-color: rgba(126, 79, 26, 0.4);
  background: #fff7ee;
}

.mind-node.is-risk,
.mind-group-tag.is-risk {
  border-color: rgba(171, 63, 78, 0.38);
  background: #fff0f2;
}

.mind-node.is-risk-source,
.mind-group-tag.is-risk-source {
  border-color: rgba(143, 76, 150, 0.38);
  background: #f8f0fa;
}

.mind-node.is-hallmark,
.mind-group-tag.is-hallmark {
  border-color: rgba(93, 90, 19, 0.4);
  background: #f8f7e7;
}

.mind-node.is-protocol,
.mind-group-tag.is-protocol {
  border-color: rgba(95, 101, 50, 0.36);
  background: #f6f8e7;
}

.mind-node.is-hallmark-modulation,
.mind-group-tag.is-hallmark-modulation {
  border-color: rgba(20, 90, 122, 0.4);
  background: #ecf7fb;
}

.mind-node.is-site,
.mind-group-tag.is-site {
  border-color: rgba(51, 95, 138, 0.38);
  background: #eef4fb;
}

.mind-node.is-stage,
.mind-group-tag.is-stage {
  border-color: rgba(54, 90, 154, 0.36);
  background: #edf2ff;
}

.mind-node.is-trial,
.mind-group-tag.is-trial {
  border-color: rgba(28, 104, 129, 0.36);
  background: #edf8fb;
}

.mind-node.is-variant,
.mind-group-tag.is-variant {
  border-color: rgba(159, 75, 99, 0.34);
  background: #fff1f6;
}

.mind-node.is-cohort,
.mind-group-tag.is-cohort {
  border-color: rgba(72, 106, 125, 0.36);
  background: #eef7fa;
}

.doc-hero {
  display: grid;
  gap: 0.55rem;
}

.doc-hero h1 {
  max-width: 18ch;
}

.bullet-list {
  margin: 0.74rem 0 0;
  padding-left: 1.04rem;
  display: grid;
  gap: 0.36rem;
  color: #5a4e42;
}

.site-note {
  text-align: center;
  color: #75675a;
  font-size: 0.83rem;
  padding: 0.42rem;
}

.reveal {
  opacity: 0;
  transform: translateY(16px);
  transition-property: opacity, transform;
  transition-duration: 560ms;
  transition-timing-function: ease;
  transition-delay: var(--delay, 0ms);
}

.reveal.is-visible {
  opacity: 1;
  transform: translateY(0);
}

.research-hero {
  position: relative;
  overflow: hidden;
}

.research-toggle {
  display: inline-flex;
  gap: 0.6rem;
  flex-wrap: wrap;
}

.research-toggle .ghost-btn.is-active {
  background: rgba(29, 111, 99, 0.16);
  border-color: rgba(29, 111, 99, 0.44);
  color: #0f3e37;
}

.research-layout {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 1rem;
}

.research-panel {
  border: 1px solid rgba(20, 38, 56, 0.1);
  border-radius: 0.9rem;
  padding: 1rem;
  background: linear-gradient(160deg, rgba(249, 251, 255, 0.95), rgba(243, 248, 247, 0.88));
}

.research-panel h3 {
  margin: 0 0 0.8rem;
}

.research-priority-list,
.research-heatmap-list {
  display: grid;
  gap: 0.6rem;
  max-height: 32rem;
  overflow: auto;
  padding-right: 0.25rem;
}

.research-point {
  border: 1px solid rgba(20, 38, 56, 0.12);
  border-radius: 0.65rem;
  padding: 0.65rem 0.75rem;
  background: rgba(255, 255, 255, 0.85);
}

.research-point h4 {
  margin: 0;
  font-size: 0.96rem;
}

.research-point p {
  margin: 0.25rem 0 0;
  font-size: 0.85rem;
  color: rgba(20, 38, 56, 0.82);
}

.research-detail-list {
  margin: 0.45rem 0 0;
  padding-left: 1.1rem;
  display: grid;
  gap: 0.35rem;
}

@media (max-width: 1020px) {
  .hero-grid,
  .lab-layout,
  .signal-controls,
  .ontology-layout,
  .mindmap-shell,
  .research-layout {
    grid-template-columns: 1fr;
  }

  .quick-facts,
  .track-grid,
  .focus-grid,
  .milestone-grid {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }
}

@media (max-width: 820px) {
  .page-shell {
    width: 94vw;
    margin-top: 0.95rem;
  }

  .topbar {
    flex-wrap: wrap;
  }

  .menu-toggle {
    display: inline-flex;
    cursor: pointer;
  }

  .nav-links {
    display: none;
    width: 100%;
    flex-direction: column;
    background: #fff9f2;
    border: 1px solid #e3d4c2;
    border-radius: 12px;
    padding: 0.42rem;
  }

  .nav-links.is-open {
    display: flex;
  }

  .nav-links a {
    width: 100%;
    border-radius: 10px;
  }

  .section-card {
    padding: 0.92rem;
    border-radius: 20px;
  }

  .mindmap-stage {
    min-height: 580px;
  }
}

@media (max-width: 620px) {
  input, select, textarea { font-size: 16px; }
  .page-shell { width: auto; margin: 0.65rem 0.65rem 1.5rem; }
  .page-shell > *, .section-card, .signal-controls label { min-width: 0; }
  .topbar { position: relative; top: 0; }
  .section-card { padding: 0.75rem; }
  .signal-controls { grid-template-columns: minmax(0, 1fr); }
  .mindmap-results { max-height: 180px; }
  .mindmap-stage { min-height: 0; cursor: auto; touch-action: pan-y; overflow: visible; padding: 0.7rem; }
  .mindmap-viewport { position: static; width: auto !important; height: auto !important; transform: none !important; }
  .mindmap-nodes { position: static; width: auto !important; height: auto !important; display: grid; gap: 0.6rem; }
  .mindmap-lines, .mindmap-zoom { display: none; }
  .mindmap-nodes .mind-node, .mindmap-nodes .mind-group-tag {
    position: static; transform: none; width: 100% !important; left: auto !important; top: auto !important;
  }
  .mindmap-nodes .mind-group-tag { margin-top: 0.6rem; white-space: normal; }
  .edge-matrix-head { display: block; }
  .edge-matrix-head .signal-meta { text-align: left; margin-top: 0.5rem; }
  .quick-facts,
  .track-grid,
  .focus-grid,
  .milestone-grid {
    grid-template-columns: 1fr;
  }

  .ontology-columns {
    grid-template-columns: 1fr;
  }

  .metric-value {
    font-size: clamp(2.3rem, 16vw, 4rem);
  }

  .mindmap-stage { min-height: 0; }

  .mindmap-filters {
    grid-template-columns: 1fr 1fr;
  }

  .mind-node {
    width: min(150px, 42vw);
  }

  .mind-node.is-center {
    width: min(200px, 52vw);
  }
}

.reveal { opacity: 1; transform: none; transition-delay: 0ms; }
a:focus-visible, button:focus-visible { outline: 2px solid var(--brand); outline-offset: 3px; }
.control-heading { font: inherit; font-weight: 600; margin: .6rem 0; }
.score-components { padding-top: .8rem; border-top: 1px solid var(--line); margin-top: .8rem; }
.research-data-note { margin: .7rem 0 0; }
.lead-note { color: var(--muted); margin-top: 1rem; }
.related-links { display: flex; flex-wrap: wrap; gap: .6rem 1.2rem; margin: .8rem 0; }
.related-links a { color: var(--brand); font-weight: 600; }
.research-layout.research-simple { grid-template-columns: minmax(0, 1fr); }
.nav-links a { white-space: nowrap; }
.mindmap-placeholder { padding: 1rem; color: var(--muted); }
.edge-matrix-table th:first-child { position: sticky; left: 0; background: #fffdf8; z-index: 1; max-width: 220px; white-space: normal; }
.edge-matrix-table button { border: 0; background: none; text-align: left; color: var(--ink); cursor: pointer; padding: 0.25rem; overflow-wrap: anywhere; }
.edge-matrix-table .has-edge { color: var(--brand); background: #f2fbf8; font-weight: 700; text-align: center; }
.edge-matrix-table .no-edge { color: var(--muted); text-align: center; }
.edge-matrix-table tr.is-selected th { background: var(--brand-soft); }

@media (prefers-reduced-motion: reduce) {
  .reveal {
    opacity: 1;
    transform: none;
    transition: none;
  }
}
/* Clinical research profiles retain visible content and locally scroll tables. */
.clinical-profile { margin-top: 2rem; min-width: 0; overflow-wrap: anywhere; }
.disease-map-page .page-shell > * { min-width: 0; }
.clinical-profile .edge-matrix-table td { white-space: normal; min-width: 110px; text-align: left; }
.clinical-profile:empty { display: none; }
.clinical-profile button { max-width: 100%; white-space: normal; text-align: left; margin: .25rem; padding: .4rem .6rem; border: 1px solid #c7d5cd; border-radius: 8px; background: #fff; color: #235749; cursor: pointer; }
.clinical-profile h4 { margin: 1.4rem 0 .5rem; }
.clinical-profile p { color: var(--muted, #52635d); }
.clinical-metrics { display: grid; grid-template-columns: repeat(3, minmax(0, 1fr)); gap: 1rem; }
.clinical-metrics article { padding: 1rem; background: #f2f6f2; border-radius: 12px; }
.clinical-metrics h4 { margin-top: 0; }
@media (max-width: 620px) { .clinical-metrics { grid-template-columns: 1fr; } }